With continuing increase of heat load in data centers and price of electricity, efficient and effective cooling of data centers has become an enormous challenge. New solutions have been developed to address this challenge including use of containments, chimney racks, in-row coolers, rear-door heat exchangers, and fan assisted tiles. However, the effectiveness and cost-benefit analysis of these solutions are not clear to data center owners and designers. Computational Fluid Dynamics (CFD) is a powerful simulation tool that can be used to evaluate the effectiveness of these solutions and demonstrate their pros and cons. In this presentation, we will use TileFlow, a commercially available CFD product, to evaluate the effectiveness of some of these solutions through a number of case studies. The proper audience for this presentation includes data center owners, facility managers, IT managers, design/consulting engineers, data center service providers, and manufacturers of cooling equipment, containments, cabinets, and perforated tiles.