Computational Fluid Dynamics (CFD) is a powerful tool for optimizing cooling performance of data centers including eliminating hot sports, minimizing wastage of airflow, and reducing energy consumption. This presentation will introduce the fundamentals of CFD technique and demonstrate its application to data centers. Comparison of CFD results with measurements will be shown to demonstrate the accuracy of CFD simulation. A commercially available CFD product named TileFlow will be used to demonstrate a case study in which common cooling problems in data centers and various solutions to these problems will be shown. These solutions include balancing airflow, minimizing wastage of cooling air, and use of partial and full containments to separate hot and cold air. The proper audience for this presentation includes data center owners, facility managers, IT managers, design/consulting engineers, data center service providers, and manufacturers of cooling equipment, containments, cabinets, and perforated tiles.